We're still old-school. We have a tape backup system that we use for the majority of our servers. onQ is kind of like doubling our protection. We like the fact that it's a complete disaster recovery solution, so if we ever lost a server, we could spin it up virtually and get our server repaired and nobody would miss any work or have even noticed a difference, other than possibly a little speed, and we're not even certain they would notice that.
We also use it for general file recovery every once in a while when somebody deletes something they shouldn't have. We use that scenario as our test, every now and then, to go in and make sure we can still recover stuff.
We use it for "insurance." We're in central Florida and in the Panhandle and it's a hurricane-prone area. We want to have things covered as much as possible, which is why we back up to the opposite office.
We have one in-house server in each of our two offices. The box in each office cross-replicates to the other. We try to put as little in the cloud as possible. We are slowly moving some things to the cloud, but as far as company data goes, we really want to manage that in-house as long as possible.